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皮质和下丘脑大脑区域的PYY调制预测了人类的食行为
Rachel L Batterham1, Dominic H ffytche, J Miranda Rosenthal
1Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK. r.batterham@ucl.ac.uk
Nature
|October 16, 2007
概括
肠道激素YY3-36 (PYY) 通过改变大脑活动来影响饮食行为. 高PYY水平将食物摄入的调节从静态转移到快乐的大脑区域,为肥胖治疗提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 人体生理学 人体生理学
- 肥胖问题研究研究
背景情况:
- 营养摄入的调节对于生存至关重要,涉及复杂的大脑电路.
- 像下丘脑这样的静态大脑区域调节身体体重,但非静态因素 (认知,情绪,奖励) 在肥胖环境中越来越多地驱动食物摄入.
- 在人体食物摄入调节中,恒常性和较高大脑中心之间的相互作用仍然不太清楚.
研究的目的:
- 在调节人类食物摄入时,研究基底在同居静止和更高大脑中心之间的相互作用的神经生物学机制.
- 检查肠道衍生的足信号,酸YY3-36 (PYY) 在调节与养行为相关的神经活动中的作用.
主要方法:
- 功能磁共振成像 (fMRI) 用于观察大脑活动.
- 在模仿被养 (高血PYY) 和禁食 (低PYY) 状态的条件下测量神经活动.
主要成果:
- YY3-36 (PYY) 调节皮质皮层/上皮层和静态大脑区域的神经活动.
- 在被养状态 (高PYY) 中,尾侧轨道前皮层的活动预测了独立于感官线索的养行为.
- 在禁食状态 (低PYY) 中,下丘脑激活预测食物摄入量,表明监管控制的切换.
结论:
- 度因子PYY将人类的食物摄入调节从静态转移到快乐 (皮质膜) 的大脑区域.
- 了解回应腹信号的恒常性和高级大脑功能的整合对于开发新型肥胖治疗至关重要.
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