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Updated: Jul 10, 2026

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
11:42

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes

Published on: November 1, 2012

识别GC基对序列的DNA小沟结合型二米丁的设计:一个二维-链相互作用图案

Manoj Munde1, Mohamed A Ismail, Reem Arafa

  • 1Department of Chemistry, Georgia State University, P.O. Box 4098, Atlanta, GA 30302-4098, USA.

Journal of the American Chemical Society
|October 16, 2007
PubMed
概括

研究人员开发了一种新的合成化合物DB1242,该化合物特别结合于富含GC的DNA序列. 这一发现挑战了传统的DNA结合模型,并为向治疗剂开辟了新的途径.

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