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作为动脉样硬化的启动过程的子内皮脂蛋白保留:更新和治疗影响

Ira Tabas¹, Kevin Jon Williams, Jan Borén

¹Department of Medicine, Columbia University Medical Center, 630 W 168th St, New York, NY 10032, USA. iat1@columbia.edu

|October 17, 2007

概括

甲基生成始于保留的阿波利波蛋白B脂蛋白. 降低这些脂蛋白降低了心血管疾病的风险,为根除提供了希望.

科学领域:

心血管科学心血管科学
脂质代谢脂质代谢是什么
免疫学免疫学免疫学

背景情况:

甲基生成是由含有阿波利波蛋白B (apoB) 的脂质蛋白在亚内皮质内保留而开始的.
这种保留触发了涉及巨细胞和T细胞的慢性炎症,促进了病变的发展.
目前的治疗重点是降低血apoB脂蛋白,以减少子内皮细胞的进入和保留.

研究的目的:

审查动脉动脉生成的病原性,重点关注脂蛋白保留和炎症反应.
讨论当前和潜在的未来治疗策略,以异构造为目标.
突出终身低ApoB脂蛋白水平在预防冠状动脉疾病中的重要性.

主要方法:

审查关于动脉动脉生成,脂蛋白代谢和心血管疾病治疗的现有文献.
对治疗方法的分析,包括他类药物和潜在的新战略.
检查人口研究,将低ApoB脂蛋白水平与心血管风险降低联系起来.

主要成果:

降低低密度脂蛋白 (LDL) 胆固醇是目前对动脉血性心血管疾病最有效的治疗方法.
未来的疗法可能包括阻断脂蛋白保留机制和向动脉壁中的辅助分子.
终身低的apoB脂蛋白水平与~90%的冠状动脉疾病风险降低有关.

结论:

了解动脉动脉发生病变,特别是脂蛋白保留,对于开发有效的治疗方法至关重要.
积极的降脂和早期开始治疗是当前治疗的关键改进.
针对保留机制和炎症反应,有望消除心血管疾病.

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