对多种被忽视的热带疾病的口服药物治疗:系统性审查
Madhuri Reddy1, Sudeep S Gill, Sunila R Kalkar
1Department of Medicine, Hebrew Rehabilitation Center, Boston, Massachusetts 02131, USA. madhurireddy@hrca.harvard.edu
JAMA
|October 24, 2007
概括
同时的口服药物治疗可以有效地管理多种被忽视的热带疾病,提高效率并减少疾病负担. 提高对这些可治疗疾病的认识对于全球控制工作至关重要.
科学领域:
- 热带医学是一种热带医学.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 被忽视的热带疾病 (NTDs) 是贫困地区普遍存在的促进贫困的条件.
- NTDs造成的疾病负担相当严重,相当于艾滋病毒/艾滋病,结核病和疟疾.
- 七种常见的NTD已经存在口服药物治疗,具有潜在的多种疾病疗效.
研究的目的:
- 系统地审查有关NTD口服药物治疗的证据.
- 提高对NTD存在和可治疗性的认识.
主要方法:
- 从1966年到2007年6月发表的随机对照试验 (RCT) 的系统综述.
- 搜索了MEDLINE数据库的RCT,这些RCT检查了七种最常见的NTD中的两个或两个以上的同时治疗.
- 专注于口服药物治疗.
主要成果:
- 确定了29个RCT,其治疗同时针对2到4种疾病.
- 组合疗法,如阿尔本达结合二甲基马зин,阿尔本达结合艾弗梅克丁,以及莱瓦米索结合梅本达,显示出疾病患病率的显著降低.
- 单一药物治疗,如单独使用阿尔本达,也证明了对多种虫感染的有效性.
结论:
- 现有的口服药物治疗可以有效地同时针对多种普遍的被忽视的热带疾病.
- 同时的治疗策略提高了治疗效率,减少了疾病负担.
- 提高全球对NTD和可用的口腔疗法的认识对于疾病控制至关重要.
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