肥胖,阿迪波金和腹腔大动脉动脉瘤:男性健康研究
Jonathan Golledge1, Paula Clancy, Konrad Jamrozik
1Vascular Biology Unit, Department of Surgery, School of Medicine, James Cook University, Townsville, QLD, Australia 4811. jonathan.golledge@jcu.edu.au
Circulation
|October 31, 2007
概括
腰围等肥胖指标与腹腔大动脉瘤 (AAA) 有关. 血清抵抗素,一种特定的阿迪波金,与AAA和大动脉直径有很强的关联.
科学领域:
- 血管生物学 血管生物学
- 肥胖问题研究研究
- 流行病学 流行病学
背景情况:
- 肥胖与封闭性动脉疾病有关.
- 传统上,肥胖不被认为是腹腔大动脉动脉瘤 (AAA) 的危险因素.
研究的目的:
- 调查肥胖,血清阿迪波金和AAA的人类测量指标之间的关联.
- 为了确定肥胖是否是AAA的独立风险因素.
主要方法:
- 使用超声波对12203名男性 (65-83岁) 进行AAA的基于人口的查.
- 测量心血管风险因素,腰和部周长.
- 在952名男性中测量了血清阿迪波金水平 (抵抗素,阿迪波内克丁,莱普).
主要成果:
- 腰围和腰比分别与AAA独立相关.
- 血清抵抗素度与AAA和大动脉直径有着强烈的独立关联.
- 血清腺素与较小的AAA有关,而丁没有显示任何关联.
结论:
- 肥胖的测量与AAA独立相关.
- 血清抵抗素与大动脉直径密切相关,比其他阿迪波金更为密切.
- 需要进一步的研究来了解抗原与AAA的联系.
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