剖析酵母半分裂的时间变化
Iftach Nachman1, Aviv Regev, Sharad Ramanathan
1FAS Center for System Biology, Harvard University, Cambridge, MA 02138, USA.
Cell
|November 6, 2007
概括
酵母半变异时间的细胞对细胞的变异性对于在不断变化的环境中生存至关重要. 这种时间主要由Ime1调节器的逐渐增加控制,而不是细胞周期或病史.
科学领域:
- 细胞生物学 细胞生物学
- 发展生物学 发展生物学
- 遗传学 是一个遗传学.
背景情况:
- 发育时间的细胞对细胞的变异性可以为在波动的环境中的人群提供适应优势.
- 在Saccharomyces cerevisiae中,变的开始是由营养饥饿引发的.
研究的目的:
- 为了调查Saccharomyces cerevisiae中介质时间的细胞间变异的来源.
- 了解这种时间变化背后的监管机制.
主要方法:
- 利用时隔光显微镜来追踪个体酵母细胞中的介质事件.
- 分析了细胞周期进展,营养史,细胞大小和介质时间之间的关系.
主要成果:
- 观测到明显的细胞对细胞的变异性,在变的持续时间.
- 鉴定出这种变异性主要集中在饥饿开始和早期 meiois 基因激活之间.
- 确定受细胞大小影响的介质调节器Ime1的生产率和逐渐增加,决定了这种时间变化.
结论:
- 介质时间的表型变化与转录调节器Ime1.1的表达动态直接相关.
- 这项研究为理解发育过程中的时间过程提供了一个框架,强调了基因表达动态的作用.
相关概念视频
Meiosis II
Meiosis II entails cell division and segregation of the sister chromatids, resulting in the production of four unique haploid gametes. The steps for meiosis II are similar to mitosis, except that meiosis II occurs in haploid cells, whereas mitosis occurs in diploid cells.
The timing and cell division patterns of meiosis differ between males and females. In male meiosis, the centrosomes are part of the formation of the meiotic spindle. However, in oocytes, including that of humans, Drosophila,...
The timing and cell division patterns of meiosis differ between males and females. In male meiosis, the centrosomes are part of the formation of the meiotic spindle. However, in oocytes, including that of humans, Drosophila,...
Meiosis vs. Mitosis
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Meiosis I
Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
Meiosis I
Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by a...


