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Updated: Jul 10, 2026

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
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Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions

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在缺氧期间,SUMO特异性蛋白酶1对于稳定HIF1alpha至关重要

Jinke Cheng1, Xunlei Kang, Sui Zhang

  • 1Department of Cardiology, The University of Texas MD Anderson Cancer Center, The University of Texas, Houston Health Science Center, Houston, TX 77030, USA.

Cell
|November 6, 2007
PubMed
概括

Sentrin/SUMO特异蛋白酶1 (SENP1) 对于胎儿发育至关重要. 失去SENP1会通过破坏低氧诱导因子1alpha (HIF1alpha) 的稳定性而导致贫血,从而影响红色素的产生.

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