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Updated: Jul 10, 2026

Steady-state, Pre-steady-state, and Single-turnover Kinetic Measurement for DNA Glycosylase Activity
14:27

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Published on: August 19, 2013

分子模拟揭示了一个常见的结合模式,用于氧化损伤的DNA病变的糖酶结合

Kun Song1, Catherine Kelso, Carlos de los Santos

  • 1Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, USA.

Journal of the American Chemical Society
|November 9, 2007
PubMed
概括

氧化性DNA损伤,如8-oxo-guanine (8OG) 和FapydG,可以导致癌症. 模拟表明,由于未保存的残留物,一种特定的酶 (Fpg) 会以不同的方式结合这些病变,从而影响修复机制.

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