登革热是因为登革热
1Supportive Research and Development, Pediatric Dengue Vaccine Initiative, Internal Vaccine Institute, Seoul, South Korea. halsteads@erols.com
Lancet (London, England)
|November 13, 2007
概括
登革热出血性发烧/登革热休克综合征 (DHF/DSS) 涉及血管透性. 本综述讨论了登革热病毒的DHF/DSS诊断,病理生理学,治疗和实验室测试.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 登革热病毒在全球范围内导致自我限制或严重的疾病.
- 严重的登革热,登革热出血性发烧/登革热休克综合征 (DHF/DSS),涉及由于细胞因子释放的血管透性.
- 流行病和严重程度受到增强和交叉反应性抗体的影响.
研究的目的:
- 审查DHF/DSS的临床诊断和病理生理学.
- 讨论 DHF/DSS 的亲肠道治疗.
- 为了强调新的登革热实验室测试.
主要方法:
- 审查关于登革热病毒感染的现有文献.
- 临床数据和病理生理机制的分析.
- 讨论治疗策略和诊断方面的进展.
主要成果:
- DHF/DSS的病理生理包括血管透性和凝血病.
- 流行病模式和疾病严重程度与抗体反应有关.
- 婴儿DHF/DSS表明其作用超出了二级T细胞反应.
结论:
- 了解登革热病理生理学对于有效管理至关重要.
- 抗体动态在登革热流行和严重程度方面发挥着关键作用.
- 诊断和治疗方面的进步对于控制DHF/DSS至关重要.
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