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相关概念视频

Long-term Potentiation01:35

Long-term Potentiation

51.6K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
51.6K
Long-term Depression01:05

Long-term Depression

27.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
27.3K
Long-term Potentiation01:25

Long-term Potentiation

2.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
2.7K
Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K
Plasticity00:58

Plasticity

2.2K
Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
2.2K
Neuroplasticity01:01

Neuroplasticity

2.6K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
2.6K

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相关实验视频

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Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
11:56

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

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一个突触记忆的痕迹,用于皮质受体场的可塑性.

Robert C Froemke1, Michael M Merzenich, Christoph E Schreiner

  • 1Coleman Memorial Laboratory and W. M. Keck Foundation Center for Integrative Neuroscience, Department of Otolaryngology, University of California, San Francisco, California 94143, USA. rfroemke@phy.ucsf.edu

Nature
|November 16, 2007
PubMed
概括

胆基底核通过暂时减少抑制,然后刺激,迅速重塑听力皮层受体场. 这种对学习至关重要的可塑性会持续数小时,形成持久的记忆痕迹.

科学领域:

  • 神经科学是一个神经科学.
  • 听觉皮层可塑性 听觉皮层可塑性
  • 突触性可塑性 突触性可塑性

背景情况:

  • 皮层受体场是可塑的,随着神经活动和经验而改变.
  • 神经调节对于皮质可塑性至关重要,但皮质下系统的相互作用尚不清楚.

研究的目的:

  • 研究成年主要听觉皮层 (AI) 中突触受体场可塑性的动态.
  • 了解基底核如何调节听觉皮层电路.

主要方法:

  • 在成年人初级听觉皮层 (AI) 的体内全细胞记录.
  • 将感官刺激与基底核激活相结合.

主要成果:

  • 基底核的激活在几秒钟内迅速减少了突触抑制,随后是对配对刺激的特定激发.
  • 在短暂的基底核刺激后,受体场的重组持续了几个小时.
  • 抑制缓慢增加以重新平衡刺激,创造新的刺激偏好.

结论:

  • 暂时的消抑制期是受感场可塑性的关键机制.
  • 这个过程可能会形成对行为显著刺激的记忆痕迹.

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