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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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IAP对抗剂向cIAP1以诱导TNFalpha依赖的亡

James E Vince1, W Wei-Lynn Wong, Nufail Khan

  • 1Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, VIC 3086, Australia.

Cell
|November 21, 2007
PubMed
概括

IAP抗剂通过激活NF-kappaB信号和TNFalpha生产来诱导瘤细胞死亡,而不仅仅是通过抑制XIAP. 阻止这种途径允许瘤细胞生存,这表明了新的癌症治疗策略.

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