相关实验视频

Updated: Jul 27, 2026

Evaluation of Mammary Gland Development and Function in Mouse Models
08:51

Evaluation of Mammary Gland Development and Function in Mouse Models

Published on: July 21, 2011

葡萄糖皮质激素刺激后受体和乳腺瘤病毒产生之间的关系

G Shyamala, C Dickson

    Nature
    |July 8, 1976
    PubMed
    概括

    葡萄糖皮质类药物通过与细胞受体相互作用,刺激乳腺瘤病毒 (MTV) 的产生. 孕激素起到对抗作用,阻断这种由葡萄糖皮质激素诱导的刺激.

    更多相关视频

    Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer07:13

    Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer

    Published on: March 26, 2014

    Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer07:45

    Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

    Published on: May 18, 2020

    相关概念视频

    Receptor Downregulation in MVBs01:15

    Receptor Downregulation in MVBs

    Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
    The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...