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Updated: Jul 9, 2026

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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通过对新生的蛋白质核友的反应性选择来实现共价催化的途径

Andrey V Reshetnyak1, Maria Francesca Armentano, Natalia A Ponomarenko

  • 1Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10, Miklukho-Maklaya str, Moscow, 117871, Russia.

Journal of the American Chemical Society
|November 30, 2007
PubMed
概括

这项研究使用了共价选择来从抗体碎片进化新的酶催化剂. 研究人员确定了特定的氨酸残留物,使得共价结合成为可能,这表明了创建原始催化场所的新方法.

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