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Identification of Kinase-substrate Pairs Using High Throughput Screening
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细胞内细菌的生长是由围绕PKB/AKT1的酶网络控制的

Coenraad Kuijl1, Nigel D L Savage, Marije Marsman

  • 1Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

Nature
|November 30, 2007
PubMed
概括

新的激酶抑制剂向宿主通路,对抗多药耐药细菌. 这些AKT1抑制剂阻断了细胞内病原体的生长,为抗击沙门氏菌 (Salmonella typhimurium) 和结核菌 (Mycobacterium tuberculosis) 等感染提供了新的策略.

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