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Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model
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Rad GTPase 缺乏导致心脏缩

Lin Chang1, Jifeng Zhang1, Yu-Hua Tseng1

  • 1Cardiovascular Center (L.C., J.Z., C.-Q.X., T.C., S.M.D., Y.E.C.), Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich; Joslin Diabetes Center (Y.-H.T., J.I., J.C.B., C.R.K.), Harvard Medical School, Boston, Mass; Institute of Molecular Medicine (Z.S., X.Z.), Peking University, Beijing, People's Republic of China; Department of Cardiology (K.A.Y.), The Methodist Hospital Research Institute, Houston, Tex; and Cardiovascular Research Institute (Q.Y.), Morehouse School of Medicine, Atlanta, Ga.

Circulation
|December 7, 2007
PubMed
概括

与糖尿病相关的Ras (Rad) GTPase抑制心脏缩. 降低心脏衰竭中的Rad水平以及在心肌细胞和小鼠中的操纵揭示了它通过-模素-依赖激酶II (CaMKII) 途径的保护作用.

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