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Intranasal Administration of CNS Therapeutics to Awake Mice
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抗生素和局部鼻类固醇用于治疗急性鼻炎:一个随机对照试验
Ian G Williamson1, Kate Rumsby, Sarah Benge
1Department of Medicine, University of Southampton, Southampton, England. igw@soton.ac.uk
JAMA
|December 7, 2007
概括
这项研究发现,阿莫西西林 (抗生素) 和布德胺 (鼻子类固醇) 在初级保健中没有有效治疗急性鼻炎. 组合疗法对鼻炎症状持续时间也没有显著的益处.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 主要护理医学 医疗保健
- 临床药理学 临床药理学
背景情况:
- 急性鼻炎是一种普遍的疾病,通常用抗生素治疗,尽管它们的疗效仍有争议.
- 局部类固醇对急性鼻炎的研究不足,尽管有潜在的抗炎功效.
研究的目的:
- 为了评估阿莫西西林和局部布德索尼德在治疗急性鼻炎的有效性.
- 为了比较抗生素和鼻子类固醇单疗与组合疗法和安慰剂.
主要方法:
- 一个双盲,随机,安慰剂控制的因子试验,涉及240名患有急性非复发性鼻炎的成年人.
- 患者接受了阿莫西西林 (500毫克三次每天7天) 和/或布松胺 (每天200毫克每天10天) 或安慰剂.
- 通过症状日记来评估临床治愈,重点关注第10天的持续时间和严重程度.
主要成果:
- 氨基没有显著减少症状持续时间 (29%与33.6%相比).
- 局部布德索尼德对症状持续时间也没有显著影响 (31.4%对31.4%).
- 鼻子类固醇在患有不太严重的基线症状的患者中似乎更有效.
结论:
- 在初级保健中,单独或组合使用的阿莫西西林和局部布迪索尼德都没有证明对急性鼻炎的有效性.
- 研究结果表明,目前的抗生素和局部类固醇疗法在研究的环境中可能对这种情况没有好处.
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