一个受体,介导Drosophila繁殖行为的交配后开关
Nilay Yapici1, Young-Joon Kim, Carlos Ribeiro
1Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.
Nature
|December 11, 2007
概括
科学家们在雌性果中发现了性受体 (SPR),它触发了交配后的行为. 了解 SPR 的理解
科学领域:
- 昆虫学 昆虫学是一门学科.
- 神经生物学 神经生物学 神经生物学
- 生殖生物学 生殖生物学
背景情况:
- 交配会在许多物种中引发雌性生殖行为的显著变化.
- 在昆虫中,雄性精液成分是这些交配后行为转变的关键媒介.
- 精确的机制,其中精液因素影响女性的行为仍然在很大程度上未被阐明.
研究的目的:
- 确定负责调解雄性 (SP) 在雌性Drosophila melanogaster中的作用的特定受体.
- 阐明这种受体在调节交配后生殖行为中的作用.
- 探索在害虫控制策略中准这种受体的潜力.
主要方法:
- 对缺乏性受体 (SPR) 的雌性Drosophila melanogaster的遗传分析.
- 行为测试比较配对和不配对的雌性,有和没有功能性SPR.
- 免疫组织化学分析以确定女性生殖道和神经系统中的SPR表达模式.
- 在不同昆虫物种中对SPR进行比较序列分析.
主要成果:
- 鉴定性质受体 (SPR,CG16752) 作为Drosophila melanogaster性质 (SP,Acp70A) 的直接受体.
- 缺少SPR的雌性,完全或在神经系统中,表现出对SP的反应失败,并在交配后保持处女行为.
- 在女性生殖道和中枢神经系统中检测到SPR表达,特别是在共同表达无果基因的神经元中.
- 在各种各样的昆虫物种中,SPR的保存程度很高.
结论:
- 性受体 (SPR) 对于调解雌性昆虫中雄性精液的行为影响至关重要.
- 在特定的神经回路中SPR的功能,包括那些涉及无果基因的神经回路,突出其在调节性别特异性生殖行为中的作用.
- 通过操纵它们的繁殖行为来控制昆虫害虫和病媒的新策略,SPR的保护性是潜在的目标.
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