为了合成有用的碳化合物的立体选择性C-H氨基化
Chungen Liang1, Florence Collet, Fabien Robert-Peillard
1Institut de Chimie des Substances Naturelles, UPR 2301, CNRS, Avenue de la Terrasse, F-91198 Gif-sur-Yvette, France.
一个新的催化反应使有效的分子间C-H氨基化使用硫 (VI) 化合物和 (III) 氧化剂. 这种方法将引入各种具有高产率和选择性的C-H键,提供新的合成途径.
科学领域:
- 有机金属化学 有机金属化学
- 催化剂是一种催化剂.
- 合成有机化学 合成有机化学
背景情况:
- 在合成化学中,C-H功能化是用于直接结合操纵的关键领域.
- 开发高效和选择性的C-H氨化方法仍然是一个重大挑战.
- 状催化剂对于控制有机转换中的立体化学是至关重要的.
研究的目的:
- 开发一种用于分子间C-H氨化的新型催化系统.
- 为了在C-H功能化反应中获得高产量和二聚体选择性.
- 探索这种方法在种族化合物的动力分辨率中的应用.
主要方法:
- 硫 (VI) 化合物的反应与 (III) 氧化剂,由 (II) 复合物催化.
- 使用一种性 ((II) 催化剂进行选性C-H氨基化.
- 使用含有原料的C-H键作为限制试剂.
主要成果:
- 形成一种高度反应的性金属酸中间体.
- 基,基和基基质的成功分子间C-H氨基化,产量高达92%.
- 观察到优异的二选择性 (高达99%),对二次C-H键有偏好反应.
- 应用到racemic sulfonimidamide的动态分辨率,证明合作作用.
结论:
- 已经建立了一个新的催化方法,用于高效和立体选择性的C-H氨基化.
- 开发的方法扩大了C-H功能化的范围,允许将引入多种C-H键.
- 这项工作突出了Csp3-H键作为功能化的多功能合成前体的潜力.
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