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心血管风险因素和静脉血栓栓塞:一个元分析
Walter Ageno1, Cecilia Becattini, Timothy Brighton
1Department of Clinical Medicine, University of Insubria, Varese, Italy. agewal@yahoo.com
Circulation
|December 19, 2007
概括
肥胖和高血压等心血管风险因素与静脉血栓栓塞 (VTE) 的风险增加有显著联系. 这一发现凸显了管理这些因素对于VTE预防的重要性.
科学领域:
- 心血管医学 心血管医学
- 血液学 血液学 血液学
- 流行病学 流行病学
背景情况:
- 静脉血栓塞栓症 (VTE) 和动脉样硬化作为不同的实体的传统观点受到共同风险因素的证据的挑战.
- 与对照组相比,患有静脉动脉瘤的患者表现出更高的无症状动脉样硬化和心血管事件率.
研究的目的:
- 进行一项元分析,评估主要心血管风险因素与VTE发生之间的关联.
- 评估这些关联对VTE查和预防策略的临床相关性.
主要方法:
- 在Medline和EMBASE数据库的系统搜索中,发现了21项病例控制和队列研究 (63,552名患者).
- 用随机效应模型提取和分析了有关心血管风险因素,研究质量和结果的数据.
- 统计异质性是使用千平方和I平方统计学来评估的.
主要成果:
- 肥胖 (OR 2.33),高血压 (OR 1.51) 和糖尿病 (OR 1.42) 与增加静脉瘤风险显著相关.
- 吸烟 (OR 1.18) 和高胆固醇血症 (OR 1.16) 显示出一种趋势.
- 静脉瘤患者的高密度脂蛋白胆固醇水平明显降低,但总和低密度脂蛋白胆固醇水平没有差异.
结论:
- 心血管风险因素被证明与静脉血栓栓塞有关.
- 这些关联对于个人查,风险因素修改以及初级和二级VTE预防具有临床意义.
- 建议进行进一步的前性研究,以阐明连接心血管风险因素和VTE的潜在机制.
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