在MEF2A基因和心肌梗塞之间缺乏关联
Wolfgang Lieb1, Björn Mayer, Inke R König
1Medizinische Klinik II, Universität zu Lübeck, Lübeck, Germany.
Circulation
|December 19, 2007
概括
遗传因素有助于冠状动脉疾病 (CAD) 和心肌梗塞 (MI). 这项研究没有发现MEF2A基因链接或与大患者和对照队伍中心肌梗塞相关的证据.
科学领域:
- 遗传学 是一个遗传学.
- 心血管疾病 心血管疾病
- 分子生物学分子生物学
背景情况:
- 遗传因素在冠状动脉疾病 (CAD) 和心肌梗塞 (MI) 中发挥着作用.
- 之前有人认为,MEF2A基因与单一家族中的MI / CAD有关.
- 之前的病例控制研究报告了MEF2A变体和MI的不一致结果.
研究的目的:
- 研究MEF2A基因在心肌梗塞 (MI) 中的作用.
- 评估MEF2A基因变异与独立患者队列和家庭中MI的关联.
主要方法:
- 在MI家族中测序MEF2A基因.
- 特定MEF2A变异的基因定型 (Pro279Leu, (CAG) 没有重复) 在大量的MI患者和对照群中.
- 使用基因芯片映射500K阵列在MEF2A区域对单核酸多态 (SNPs) 的分析.
主要成果:
- 在23个MI家族中,MEF2A基因中没有发现突变.
- 在案例控制研究中,Pro279Leu变异和 (CAG) n重复没有与MI / CAD相关.
- 区域范围的SNP分析未能提供MEF2A和MI (P=0.23) 之间关联的证据.
结论:
- 这项研究没有发现MEF2A基因与心肌梗塞的联系或关联的证据.
- 对1700多名心脏病发作患者和大型对照群体的分析不支持MEF2A作为心脏病发作的主要易感基因.
- 这些发现表明,MEF2A不太可能是研究群体中MI的显著遗传贡献者.
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