合成和对玛氨基酸的构造性研究
Fei Chen1, Ke-Sheng Song, Yun-Dong Wu
1Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, People's Republic of China.
Journal of the American Chemical Society
|December 20, 2007
概括
研究人员合成了新的-氨基酸和,发现了独特的螺旋结构,由称为"N-O转"的分子内键稳定. 侧链修改控制转形成和螺旋稳定性.
科学领域:
- 酸的化学结构
- 有机合成 有机合成
- 结构生物学是结构生物学.
背景情况:
- 氨基酸是合成的新型构建块.
- 了解形状对于药物设计和材料科学至关重要.
研究的目的:
- 合成和表征一系列的氨基酸及其相应的.
- 研究这些新型的结构性质,特别是分子内键和螺旋结构的形成.
主要方法:
- 用各种替代物 (未被替代的,gamma4-Ph,gamma4-alkyl,gamma(3,4) -cyclohexyl) 合成玛氨基酸单体.
- 使用EDCI/HOBt (或HOAt) 的合.
- 使用理论研究和实验观察的形式分析.
主要成果:
- 成功合成多种玛氨基酸衍生物和.
- 在相邻的残留物之间观测10个成员环的分子内键 ("gamma N-O turns").
- 侧链置换显著影响马N-O转形成的程度.
- 由连续的gamma N-O转动引起的新型螺旋结构的形成.
- 理论研究成功地合理化了观察到的形状特征.
结论:
- 玛氨基具有独特的结构性质,由"玛N-O转".
- 这项研究揭示了这些的新型螺旋结构.
- -氨基酸的侧链工程提供了对二次结构的控制.
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