补充剂对老年男性的功能移动性,认知和其他参数的影响:一项随机对照试验
Marielle H Emmelot-Vonk1, Harald J J Verhaar, Hamid R Nakhai Pour
1Department of Geriatric Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. m.h.emmelotvonk@umcutrecht.nl
JAMA
|January 3, 2008
概括
老年男性服用丸激素补充剂并没有改善身体功能或认知能力. 然而,它增加了瘦身量,对代谢健康产生混合影响,没有观察到不良的前列腺结果.
科学领域:
- 老年学是一门学科.
- 内分泌学 在内分泌学.
- 男人的健康 男人健康
背景情况:
- 在男性中,血清丸激素水平自然会随着年龄的增长而下降.
- 补充剂可能对老年男性的衰老过程有好处.
- 低正常丸激素水平在老年男性中很常见.
研究的目的:
- 评估丸激素补充剂对老年男性的功能性移动性,认知,骨密度,身体组成,脂质和生活质量的影响.
- 在这个人口群体中评估丸激素补充剂的安全性.
主要方法:
- 一项为期6个月的,双盲,随机,安慰剂对照试验,涉及237名60-80岁的健康男性,他们的丸激素水平正常低.
- 参与者接受了非酸盐 (每天两次80毫克) 或安慰剂.
- 综合性评估包括功能性移动性,认知功能,骨矿物质密度,身体组成,代谢风险因素,生活质量和安全参数.
主要成果:
- 随着丸激素的使用,瘦体质量增加,脂肪质量减少,但功能性移动性和肌肉力量没有改善.
- 认知功能和骨矿物质密度保持不变.
- 胰岛素敏感性有所改善,但高密度脂蛋白胆固醇降低,代谢综合征的患病率显示,丸激素组的增加趋势不显著.
结论:
- 在低正常水平的老年男性中,六个月的丸激素补充剂没有提高功能状态或认知能力.
- 丸激素治疗增加了瘦体质量,但产生了混合的代谢效应.
- 没有观察到对前列腺安全的负面影响.
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