相关实验视频
红细胞分布宽度与冠状动脉疾病患者心血管事件率之间的关系
Marcello Tonelli1, Frank Sacks, Malcolm Arnold
1Division of Nephrology and Immunology, University of Alberta, 7-129 Clinical Science Building, 8440 112 St, Edmonton, Alberta T6B 2B7, Canada. no_reprints@med.ualberta.ca.
Circulation
|January 4, 2008
概括
较高的红细胞分布宽度 (RDW) 与冠状动脉疾病患者的死亡率和心血管事件增加有关. 这一发现突出了RDW作为潜在的风险指标,即使在没有心力衰竭的人中也是如此.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 临床流行病学临床流行病学
背景情况:
- 红细胞分布宽度 (RDW) 的增加与心力衰竭患者的不良结果有关.
- 在没有心力衰竭的冠心病患者中,RDW的预后价值需要进一步调查.
研究的目的:
- 评估基线RDW与全因死亡率和心血管不良结果的风险之间的关联.
- 确定RDW是否是冠状动脉疾病但没有基线心力衰竭的个体中死亡率和心血管事件的独立预测因素.
主要方法:
- 对胆固醇和复发性事件 (CARE) 研究数据的后期分析.
- 包括4111名随机分配给普拉瓦斯塔丁或安慰剂的参与者,与基线RDW测量.
- 利用考克斯的比例危险模型来分析RDW与临床结果之间的关系,平均随访时间为59.7个月.
主要成果:
- 在较高的基线RDW和所有原因死亡率调整后风险增加之间发现了显著的关联 (HR每百分比增加1.14).
- 观察到RDW四分位数与死亡率之间的分级独立关系 (P为趋势=0.001),最高四分位数显示死亡风险增加1.78倍.
- 较高的RDW水平也与冠状动脉死亡/心肌梗塞,新心力衰竭和中风的风险增加有关.
结论:
- 更高的红细胞分布宽度 (RDW) 独立地与死亡和心血管事件的风险增加有关.
- 在患有冠状动脉疾病的患者中,RDW可以作为一个有价值的预后生物标志物,即使没有症状的心力衰竭.
- 这些发现表明,RDW在心血管风险分层中的作用更广泛,超出了心力衰竭人群.
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