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相关概念视频

Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...

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Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes
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自适应的催化剂:基质依赖的连接体配置.

Raivis Zalubovskis1, Alexis Bouet, Ester Fjellander

  • 1KTH School of Chemical Science and Engineering, Department of Chemistry, Organic Chemistry, SE 100 44 Stockholm, Sweden.

Journal of the American Chemical Society
|January 18, 2008
PubMed
概括

具有柔性连接体的帕拉复合体在基化反应中将其结构适应不同基质. 这种结构适应性解释了不同基系统观察到的不同催化行为.

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科学领域:

  • 有机金属化学 有机金属化学
  • 催化剂是一种催化剂.
  • 有机合成 有机合成

背景情况:

  • 催化基化是有机合成中的一个关键反应.
  • 了解催化中间体的结构是优化反应结果的关键.
  • 连接体构造显著影响催化反应的立体化学路径.

研究的目的:

  • 为了研究在复合体中配置不稳定的联结体的构造性行为.
  • 为了建模催化性基化中的中间体.
  • 为了将连接体结构与催化活性和选择性相关联.

主要方法:

  • 核磁共振 (NMR) 光谱学 核磁共振 (NMR) 光谱学
  • 密度函数理论 (DFT) 的计算.
  • 在X射线晶体学.

主要成果:

  • 连接体在Pd(II) 基复合体中采用C(s) 构造.
  • 根据基系统,基体在Pd(0) 烯酸复合体中表现出不同的构造.
  • 在溶液和固体状态下证实了复合物的结构适应性.
  • 观察到的结构偏好与不同酸在催化基化中的活性相关.

结论:

  • 这种配置不稳定的联体体表现出显著的结构灵活性.
  • 复合物可以调整其结构以适应各种基质,从而影响催化结果.
  • 这项研究提供了对催化基化的机制和连接体设计的作用的见解.