部脂肪组织炎症在阿波利波蛋白E缺乏的小鼠中加速动脉样硬化
Miina K Ohman1, Yuechun Shen, Chinyere I Obimba
1University of Michigan, Department of Internal Medicine, Division of Cardiology, Ann Arbor 48109-0644, USA.
Circulation
|January 24, 2008
概括
内脏脂肪炎症在小鼠中加速动脉样硬化,而皮下脂肪则没有. 皮奥格利塔可以通过向炎症性内脏脂肪来减少这种血管疾病.
科学领域:
- 肥胖和代谢疾病研究研究.
- 血管生物学和动脉样硬化
- 脂肪组织生物学和炎症
背景情况:
- 与肥胖相关的并发症,包括动脉样硬化,可能涉及脂肪炎症.
- 脂肪组织在代谢调节和炎症中起着至关重要的作用.
研究的目的:
- 为了研究移植脂肪组织对动脉样硬化的影响.
- 为了确定内脏脂肪炎症是否加速血管疾病.
- 探索针对内脏脂肪炎症的潜在治疗策略.
主要方法:
- 从野生类型的小鼠移植了流行性脂肪,移植到缺乏莱普的 (Lep(ob/ob)) 和易患动脉样硬化症的阿波利波蛋白E缺乏 (ApoE(-/-))) 的小鼠中.
- 分析了移植脂肪中的巨细胞透和炎症标志物.
- 在接受者小鼠中评估了动脉样硬化发展.
- 评估了皮奥格利塔治疗对炎症和动脉样硬化的影响.
主要成果:
- 在Lep(ob/ob) 小鼠中移植的脂肪显示了巨细胞透的增加,类似于肥胖脂肪.
- 与假冒手术相比,将内脏脂肪移植到ApoE的小鼠中大大增加了动脉样硬化.
- 皮下脂肪移植没有影响动脉样硬化,尽管有类似的炎症.
- 皮奥格利塔治疗减少了移植的内脏脂肪中的炎症,并减少了接受小鼠的动脉样硬化.
结论:
- 与内脏脂肪组织相关的炎症在小鼠中加速动脉样硬化.
- 与皮奥格利塔一样,提亚索利丁二子可能有效减轻由内脏炎症脂肪驱动的血管疾病.
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