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相关概念视频

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
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Published on: August 14, 2018

可编程DNA的纳米粒子结晶.

Sung Yong Park1, Abigail K R Lytton-Jean, Byeongdu Lee

  • 1Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.

Nature
|February 1, 2008
PubMed
概括

研究人员使用DNA功能化黄金纳米粒子演示可编程的合体结晶. 不同的DNA序列引导纳米粒子组装成不同的面部中心立方体或身体中心立方体晶体结构.

科学领域:

  • 纳米技术纳米技术
  • 材料科学 材料科学 材料科学
  • 生物技术是生物技术.

背景情况:

  • 功能化DNA纳米粒子是已知的诊断工具.
  • 通过DNA相互作用将纳米粒子组装成有序材料是不发达的.
  • 以前的努力产生了具有有限结构控制的无形聚合物.

研究的目的:

  • 为了证明对纳米粒子组装到不同的晶体状态的理性控制.
  • 探索使用DNA序列作为合结晶的可编程指南.
  • 为了实现对组装材料中的粒子放置,周期和粒子间距离的控制.

主要方法:

  • 合成具有特定DNA寡核酸功能的金纳米颗粒.
  • 利用可编程的DNA基配对相互作用来直接纳米粒子自我组装.
  • 修改DNA序列和链接分子以影响晶体结构的形成.
  • 研究单基器对组装结果的影响.

主要成果:

  • 证明不同的DNA序列可以将相同的金纳米颗粒引导到不同的晶体结构中.
  • 取得了微米大小的面部中心立方体和身体中心立方体晶体的形成.
  • 展示了纳米粒子组装可以通过调整DNA序列和链接分子来精确控制.

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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
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Published on: January 7, 2019

Crystallization of Proteins on Chip by Microdialysis for In Situ X-ray Diffraction Studies
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Crystallization of Proteins on Chip by Microdialysis for In Situ X-ray Diffraction Studies

Published on: April 11, 2021

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Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
09:15

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Published on: August 14, 2018

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

Crystallization of Proteins on Chip by Microdialysis for In Situ X-ray Diffraction Studies
12:38

Crystallization of Proteins on Chip by Microdialysis for In Situ X-ray Diffraction Studies

Published on: April 11, 2021

结论:

  • 合成可编程的纳米颗粒的合结晶是可以实现的.
  • 一种单一类型的纳米粒子可以根据DNA编程来形成不同的晶体结构.
  • 这项工作推动了从纳米粒子构建块中开发高度排序的宏观材料的发展.