系统白细胞导向的siRNA输送显示了环素D1作为一种抗炎性标
Dan Peer1, Eun Jeong Park, Yoshiyuki Morishita
1Immune Disease Institute and Department of Anesthesia, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
Science (New York, N.Y.)
|February 2, 2008
概括
这项研究揭示了Cyclin D1 (CyD1) 作为一种潜在的抗炎性标. 在白细胞中抑制CyD1通过减少炎症和免疫细胞增殖来逆转实验性结肠炎.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 纳米医学是一种纳米医学.
背景情况:
- 环素D1 (CyD1) 是一个关键的细胞循环调节剂和癌症标.
- 在炎症中,CyD1的调节升高,但其作用尚不清楚.
研究的目的:
- 研究CyD1在炎症中的作用.
- 开发一种针对白细胞中CyD1抑制的有针对性的方法.
主要方法:
- 开发了载有CyD1-小干扰RNA (siRNA) 的目标稳定纳米粒子 (tsNP).
- 使用β(7) 整合素抗体在体内向特定白细胞子集.
- 在实验诱导的大肠炎的小鼠中,系统地给出beta(7) I-tsNP.
主要成果:
- 在白细胞中使用向的 tsNP 成功静止 CyD1.
- 在小鼠中逆转实验性大肠炎.
- 已证明抑制白细胞增殖和T辅助细胞1细胞因子表达.
结论:
- 环素D1是一种可行的抗炎性标.
- 通过TSNP进行向siRNA传递是炎症性疾病的可行治疗策略.
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