在年轻成年人中吸食大麻和牙周病
W Murray Thomson1, Richie Poulton, Jonathan M Broadbent
1Department of Oral Sciences, Sir John Walsh Research Institute, School of Dentistry, Dunedin, New Zealand. murray.thomson@otago.ac.nz
JAMA
|February 7, 2008
概括
吸食大麻是牙周病的危险因素,独立于吸烟. 较高的大麻暴露显著增加了患牙周病的风险,即使考虑到吸烟.
科学领域:
- 口腔健康研究研究 口腔健康研究
- 流行病学 流行病学
- 药物使用研究 药物使用研究
背景情况:
- 烟草吸烟是牙周病的已知危险因素之一.
- 大麻吸烟对牙周病的潜在贡献正在调查中.
- 吸烟的系统性影响可能会将烟草和大麻与口腔健康结果联系起来.
研究的目的:
- 调查大麻吸烟是否是牙周病的危险因素.
- 评估大麻使用与牙周病发病率和严重程度之间的关联.
主要方法:
- 新西兰出生队列的前性队列研究 (n=903) 出生于1972-1973.
- 在18,21,26,32岁时评估大麻使用情况;26岁和32岁时测量牙周状况.
- 牙周病通过每颗牙3个位点的联合粘附损失 (CAL) 确定;对烟草吸烟和其他共同变量进行控制的分析.
主要成果:
- 高度大麻暴露与牙周病的风险增加有关.
- 高度大麻暴露的相对风险:为≥4mmCAL的1.6,为≥5mmCAL的3.1,为事件依恋丧失的2.2.
- 随着大麻暴露水平 (6.5%没有,11.2%有些,23.6%高) 的增加,事件依恋损失增加.
结论:
- 吸食大麻可能是牙周病的独立风险因素.
- 研究结果表明,大麻使用有助于牙周病的进展.
- 需要进一步的研究来阐明将大麻与牙周病联系在一起的机制.
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