帕拉催化化的阿里尔托西拉酸和梅西拉酸
Rachel H Munday1, Joseph R Martinelli, Stephen L Buchwald
1Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
一种新的催化碳化方法在温和的条件下有效地合成了来自酸和酸的. 这种多功能协议展示了广泛的基质范围和对有机合成的优良功能组耐受性.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 合成方法论 合成方法论
背景情况:
- 催化反应在现代有机合成中至关重要.
- 对药品和材料而言,的高效合成至关重要.
- 酸和酸是常见的合成中间体.
研究的目的:
- 开发一个一般的协议,用于催化碳化的aryl tosylates和mesylates.
- 在温和高效的条件下合成.
- 为了证明广泛的基质范围和功能组耐受性.
主要方法:
- 使用了酸 (Pd(OAc) 2) 和dcpp联体催化剂系统.
- 在大气一氧化碳 (CO) 压力下进行的反应.
- 在80-110°C的温度下运行.
主要成果:
- 成功开发了一种用于合成的通用协议.
- 实现了电子丰富,电子贫乏和异环基质的碳化.
- 在开发的方法中表现出广泛的功能组耐受性.
结论:
- 开发的催化碳化提供了一个温和而高效的路径以.
- 该协议的广泛范围和宽容性使其对各种合成应用具有价值.
- 这种方法扩大了在有机合成中aryl tosylates和mesylates的实用性.
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