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二次突变作为BRCA2突变癌症中西斯普拉丁耐药性的机制

Wataru Sakai1, Elizabeth M Swisher, Beth Y Karlan

  • 1Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.

Nature
|February 12, 2008
PubMed
概括

在BRCA2中发生的二次突变可能会导致BRCA2突变癌症对西斯普拉丁化疗产生抗性. 这些BRCA2基因突变恢复正常功能,导致对类药物和PARP抑制剂的耐药性.

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