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Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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由于BRCA2中的内基因缺失引起的治疗耐药性

Stacey L Edwards1, Rachel Brough, Christopher J Lord

  • 1The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.

Nature
|February 12, 2008
PubMed
概括

在具有BRCA2突变的癌细胞中可能出现对PARP抑制剂的耐药性. 这通过特定的删除来恢复BRCA2功能,使DNA修复和降低对这些药物的敏感性.

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