瘤性BRAF通过由分泌的蛋白质IGFBP7介导的途径诱导衰老和亡

Narendra Wajapeyee1, Ryan W Serra, Xiaochun Zhu

  • 1Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Cell
|February 13, 2008
PubMed
概括

激活BRAFV600E瘤基因会触发IGFBP7的分泌,矛盾的是,它会阻止细胞生长. 这一发现为黑色素瘤的发展和潜在的治疗点提供了新的见解.

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