相关实验视频

Updated: Jun 18, 2026

Combined DNA-RNA Fluorescent In situ Hybridization (FISH) to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells
15:54

Combined DNA-RNA Fluorescent In situ Hybridization (FISH) to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells

Published on: June 14, 2014

X 无活化计数和选择是一个随机的过程:证据表明X链接激活器的参与

Kim Monkhorst1, Iris Jonkers, Eveline Rentmeester

  • 1Department of Cell Biology, Erasmus Medical Center, P.O. Box 2040, Rotterdam 3000 CA, The Netherlands; Department of Reproduction and Development, Erasmus Medical Center, P.O. Box 2040, Rotterdam 3000 CA, The Netherlands.

Cell
|February 13, 2008
PubMed
概括

雌性哺乳动物细胞使用X染色体失活 (XCI) 来补偿基因剂量. 这项研究揭示了一种随机机制,每个X染色体独立地根据其与细胞 ploidy 的比率启动XCI.

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A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome

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相关概念视频

X-Inactivation01:58

X-Inactivation

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Inheritance of Chromatin Structures

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Dosage Compensation

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X-inactivation01:58

X-inactivation

The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
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Deactivation Processes: Jablonski Diagram

Luminescence, the emission of light by a substance that has absorbed energy, is a process that involves the interaction of molecules with light. The energy-level diagram, or Jablonski diagram, is a graphical representation of these interactions, illustrating the various states and transitions a molecule can undergo. In a typical Jablonski diagram, the lowest horizontal line represents the ground-state energy of the molecule, which is usually a singlet state. This state represents the energies...