后调节的长期好处是后调节.
Hélène Thibault1, Christophe Piot, Patrick Staat
1Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Circulation
|February 13, 2008
概括
在急性心肌梗塞患者中,缺血后调节显著减少了心脏病发作的大小,并改善了长期的心脏功能. 这种保护作用在最初事件发生数月后仍然存在,从而增强恢复.
科学领域:
- 心脏病学 心脏病学
- 心血管研究研究心血管研究
- 再生医学是一种再生医学.
背景情况:
- 之前已经表明,缺血后调节可以减少肌酸激酶释放,这是急性心肌梗塞 (AMI) 中心脏病发作大小的标记.
- 研究了后调节对AMI患者心肌梗塞大小和心肌功能恢复的长期影响.
研究的目的:
- 为了确定缺血后调节是否提供持续性心脏病发作大小限制.
- 评估后调节是否能改善心肌收缩功能在心脏病发作后几个月恢复.
主要方法:
- 38名患有第一次ST段升高心肌梗塞,接受皮肤冠状动脉干预的患者被随机分组.
- 补充条件涉及反复的血管塑造气球膨胀/膨胀在再注射后.
- 6个月后通过酶释放和201thallium SPECT评估心脏病发作的大小;1年后通过心声学评估收缩功能.
主要成果:
- 调节后组在6个月后显示出明显较小的心脏病发作大小 (11.8%与19.5%的SPECT指数相比,P=0.04).
- 在后调节组中观察到减少的肌酸激酶 (-40%) 和热素I (-47%) 释放.
- 后调节患者在1年内左心室喷射分数增加了7% (P=0.04).
结论:
- 缺血后调节可以在AMI患者中持续减少心脏病大小.
- 后调节可以改善心肌收缩功能的长期恢复.
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