在美国成年人中,饮食鱼类和omega-3脂肪酸消费以及心率变化
Dariush Mozaffarian1, Phyllis K Stein, Ronald J Prineas
1Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, USA. dmozaffa@hsph.harvard.edu
Circulation
|February 21, 2008
概括
吃鱼和omega-3与老年人更好的心率变化 (HRV) 有关. 这表明阴道活动和巴罗受体反应得到改善,可能降低心脏死亡风险.
科学领域:
- 心脏病学 心脏病学
- 营养科学 营养科学
- 生理学 生理学 生理学
背景情况:
- 众所周知,食用鱼和omega-3脂肪酸可以降低心脏病死亡风险,但根本机制尚不清楚.
- 心率变化 (HRV) 是心脏死亡的预测指标,反映了电生理路径.
- 这项研究研究了鱼/欧米茄-3摄入量与HRV之间的关联.
研究的目的:
- 检查习惯性鱼类和海洋omega-3脂肪酸消费与心率变化 (HRV) 之间的关系.
- 阐明潜在的电生理学机制,将饮食与心脏风险联系起来.
- 为了支持鱼类消费对临床风险因素所观察到的影响.
主要方法:
- 基于人口的美国老年人队列的横截面分析 (n=4263为心电图,n=1152为霍尔特).
- 评估过去一年通常的食鱼类和omega-3摄入量.
- 针对潜在的混因素进行多变量调整.
主要成果:
- 鱼/鱼类的消费与HRV的增加有关,这表明更大的阴道主导和缓和的巴罗受体反应.
- 具体的HRV指数有所改善,包括更高的根平均平方连续差异和正常化的高频功率,以及更低的低频/高频比率.
- 鱼类摄入量也与较少不规律的鼻腔节点发射相关,由较低的普恩卡雷比率和更高的短期碎形缩放指数表明.
结论:
- 习惯性食用鱼类和海洋omega-3脂肪酸与老年人中有利的HRV模式有关.
- 这些模式表明改善了阴道活动,巴罗受体功能和鼻腔节点调节.
- 需要进一步的研究来探索细胞机制和对心脏风险降低的临床影响.
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