相关实验视频
Updated: Feb 7, 2026
01:29
GPI Anchoring of Proteins in the ER Membrane
5.6K
CD137在人类动脉样硬化中表达,并促进高胆固醇贫血小鼠中斑块炎症的发展
Peder S Olofsson1, Leif A Söderström, Dick Wågsäter
1Center for Molecular Medicine, L8:03, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden. Peder.Olofsson@ki.se
Circulation
|February 21, 2008
概括
参与自身免疫性疾病的CD137-CD137L通路促进动脉样硬化. 这种相互作用增加了炎症和白细胞的招募,有助于疾病的进展.
科学领域:
- 免疫学 免疫学 免疫学
- 心血管生物学 心血管生物学
- 动脉样硬化的发病因子
背景情况:
- 炎症是动脉样硬化发展和进展的核心因素.
- 包括CD40/CD40L和OX40/OX40L在内的瘤坏死因子超级家族分子与动脉样硬化过程有关.
研究的目的:
- 研究CD137及其连接体 (CD137L) 在动脉样硬化病变发生过程中的作用.
- 确定CD137-CD137L相互作用是否有助于动脉样硬化病变的发展和炎症.
主要方法:
- 在人类动脉样硬化病变中检测CD137蛋白.
- 诱导CD137在内皮和光滑肌细胞中的表达,由益炎性细胞因子.
- 在体外评估CD137激活对内皮细胞和光滑肌细胞的影响.
- 给非脂质蛋白E缺乏的小鼠服用CD137激动剂,以评估对动脉样硬化的影响.
主要成果:
- 在人类动脉样硬化病变中的T细胞,内皮细胞和光滑肌细胞上发现了CD137蛋白.
- 促炎性细胞因子在培养的内皮细胞和光滑肌肉细胞中诱导了CD137的表达.
- 通过CD137L激活CD137,增加了内皮粘附分子的表达,减少了光滑肌肉细胞的增殖.
- 在小鼠中使用CD137激动剂治疗加剧了动脉样硬化炎症,T细胞透和细胞因子表达.
结论:
- CD137-CD137L相互作用代表了动脉生成中的病原性途径.
- 这些相互作用通过增强白细胞招募和炎症来促进动脉样硬化.
- 向CD137-CD137L轴可能为动脉样硬化提供治疗策略.
相关概念视频
GPI Anchoring of Proteins in the ER Membrane
5.6K
GPI-anchoring is a post-translational, reversible protein modification that is ubiquitous in eukaryotes. Such proteins are primarily present on the exoplasmic leaflet of the plasma membrane.
GPI-anchor structure
A sequence of 11 enzymatic reactions results in the synthesis of the complete GPI anchor consisting of a hydrophobic and a hydrophilic portion. The hydrophobic portion comprises phosphatidylinositol, while the hydrophilic part comprises polar groups like phosphoethanolamine,...
GPI-anchor structure
A sequence of 11 enzymatic reactions results in the synthesis of the complete GPI anchor consisting of a hydrophobic and a hydrophilic portion. The hydrophobic portion comprises phosphatidylinositol, while the hydrophilic part comprises polar groups like phosphoethanolamine,...
5.6K
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
1.3K
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
1.3K
The Anchoring-and-Adjustment Heuristic
7.8K
In order to make good decisions, we use our knowledge and our reasoning. Often, this knowledge and reasoning is sound and solid. However, sometimes, we are swayed by biases or by others manipulating a situation. For example, let’s say you and three friends wanted to rent a house and had a combined target budget of $1,600. The realtor shows you only very run-down houses for $1,600 and then shows you a very nice house for $2,000. Might you ask each person to pay more in rent to get the...
7.8K
Anchoring Junctions
5.0K
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
5.0K
Lipids as Anchors
7.4K
In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains...
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains...
7.4K
Complement System
10.8K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
10.8K