一种光合作用膜,与虫复合体寄生虫密切相关
Robert B Moore1, Miroslav Oborník, Jan Janouskovec
1School of Molecular and Microbial Biosciences, University of Sydney, Darlington, New South Wales 2006, Australia.
Nature
|February 22, 2008
概括
研究人员发现了一种新型的光合作用生物体,与引起疟疾的Apicomplexa寄生虫密切相关. 这一发现为研究虫细胞进化和Apicomplexa寄生虫的起源提供了一个新的模型.
科学领域:
- 海洋生物学 海洋生物学
- 寄生虫学的寄生虫学
- 进化生物学 进化生物学
背景情况:
- 包括Plasmodium falciparum在内的Apicomplexa寄生虫具有非光合作用虫体,这是抗疟疾药物开发的关键目标.
- 在此之前,Apicomplexa与功能性光合作用塑性质的近亲没有被确定.
- 了解虫细胞的进化起源对于开发新的治疗策略至关重要.
研究的目的:
- 描述一种新培养的有机体,具有与Apicomplexa相关的超结构性和植物遗传特征.
- 调查其光合作用塑的性质和进化意义.
- 建立一个模型系统来研究在Apicomplexa.寄生虫的进化.
主要方法:
- 对新培养的生物体进行超结构分析.
- 使用塑体和核核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核糖核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核核
- 对psbA基因的基因分析,包括托的代码使用.
主要成果:
- 培养了一种新的气泡状生物体,与Apicomplexa. phylogenetically相关.
- 这种生物体拥有一种色素甲,四膜结合的光合作用塑体.
- 塑利用UGA编码子用于托,这是与虫类囊细胞和线粒体共享的一种特征.
结论:
- 这种发现的生物是已知最接近Apicomplexa的光合作用生物.
- 它的塑与寄生虫Apicomplexa中发现的虫细胞具有共同的进化起源.
- 这种生物可以作为一个有价值的模型来研究虫细胞进化和转变为寄生虫的过程.
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