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肥胖对左心室质量和几何学的影响. 弗雷明汉心脏研究
M S Lauer1, K M Anderson, W B Kannel
1Charles A. Dana Research Institute, Boston, Mass.
JAMA
|July 10, 1991
概括
肥胖会显著增加左心室质量,即使考虑到年龄和血压,也会影响心脏结构. 较高的体重指数与更大的心肌厚度和腔室大小有关.
科学领域:
- 心脏病学 心脏病学
- 肥胖问题研究研究
- 流行病学 流行病学
背景情况:
- 肥胖是一个日益严重的公共卫生问题,可能会对心血管产生影响.
- 了解肥胖对心脏结构的影响对于风险评估至关重要.
研究的目的:
- 为了研究不同程度的肥胖与左心室质量和几何之间的关联.
- 确定肥胖症是心脏结构变化的独立预测因素.
主要方法:
- 一项以人口为基础的流行病学研究,涉及3922名来自弗雷明汉心脏研究的健康参与者.
- 使用M模式回声心电图来评估左心室质量.
- 体重指数 (BMI) 从测量身高和体重计算出来,以量化肥胖.
主要成果:
- 在体质指数和左心室质量之间观察到强烈的相关性.
- 体重指数独立预测左心室质量,壁厚和内部尺寸 (P < .01).
- 肥胖 (BMI>30 kg/m2) 与心声图左心室缩的患病率增加有关.
结论:
- 肥胖与左心室质量增加显著相关,独立于年龄和血压.
- 增加脂肪导致左心室质量增加,通过增加壁厚和内部尺寸.
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