更年期 更年期 绝经
1Oregon Evidence-based Practice Center, Department of Medical Informatics and Clinical Epidemiology, OR, USA. nelsonh@ohsu.edu
Lancet (London, England)
|March 4, 2008
概括
更年期标志着由于卵巢激素的下降而导致月经结束. 虽然这是一个自然的过渡期,但只有热和阴道干燥与更年期有着一致的联系,治疗结果不一.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 妇女健康 妇女健康
- 临床妇科 临床妇科
背景情况:
- 更年期是一个自然的生物过程,由月经周期的停止来定义.
- 它的特点是卵巢激素的分泌量减少,主要是雌激素和孕激素.
- 虽然这是一个正常的生活事件,但症状管理是医疗咨询的常见原因.
研究的目的:
- 审查已确定的更年期症状.
- 评估各种治疗治疗更年期症状的疗效和安全性.
- 识别了解更年期过渡及其健康影响的知识差距.
主要方法:
- 对有关更年期相关症状的流行病学研究进行系统审查.
- 对针对血管运动功能障碍的治疗方法的临床试验数据的分析.
- 评估与更年期症状治疗相关的不良影响.
主要成果:
- 血管运动功能障碍 (发热) 和阴道干燥是流行病学研究中唯一一贯与更年期相关的症状.
- 包括雌激素, gabapentin, paroxetine 和 clonidine 在内的疗法在血管运动功能障碍方面表现出有效性.
- 其他常见的症状,如情绪变化和睡眠障碍,可能是继发性或与更年期无关.
结论:
- 更年期是一个复杂的过渡期,症状在个体之间有很大差异.
- 对于关键的更年期症状存在有效的管理策略,但治疗疗效和副作用需要仔细考虑.
- 需要进一步的研究来解决关于更年期过渡及其长期健康影响的许多未解答的问题.
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