心肌组织生长的跨体分布,由体积过载过度的缩诱导,在狗
1Department of Medicine, University of California San Diego, La Jolla 92093-0613.
Circulation
|September 1, 1991
概括
慢性体积过载会导致均的心脏膨胀,增长在左心室壁上均发生. 这项研究揭示了这一过程中纤维交叉的显著增长.
科学领域:
- 心血管生理学心血管生理学
- 进行心脏重塑.
- 生物机械工程 生物机械工程
背景情况:
- 慢性体积过载通常会导致心脏膨胀.
- 驱动这种组织生长的特定机械刺激仍然没有定义.
- 拟议的因素包括扩张和收缩压力/应变的变化,以及潜在的跨度变化.
研究的目的:
- 为了研究心肌组织生长的三维模式,以应对慢性体积过载.
- 评估组织生长的跨壁变化及其与机械因素的关系.
- 为了确定体积过载诱导心脏缩的刺激.
主要方法:
- 在狗的左心室前自由壁植入金珠,以追踪组织变形.
- 创建了一个全身动脉静脉,以诱导慢性体积过载.
- 在心脏扩大之前和之后,在受控的末端透气压力下测量了珠子配置.
- 使用有限元分析来得出连续的跨壁菌株分布.
主要成果:
- 心脏膨胀发生在恒定的终端-透析壁厚度和增加的左心室直径.
- 心肌质量在左心室壁上均增加 (20-27%).
- 跨壁生长菌株在周长和纵向方向均和阳性.
- 观察到显著的横纤维生长,大约与平面内纤维生长大小相等.
结论:
- 对体积过载缩的刺激似乎在心肌壁上是恒定的.
- 在体积过载诱导的心脏缩期间,横纤维方向发生了实质性的增长.
- 研究结果表明,机械刺激可能不会在跨壁上发生变化,从而导致缩.
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