小鼠的1型糖尿病与1号染色体上的介白素-1受体和Lsh/Ity/Bcg基因有关
R J Cornall1, J B Prins, J A Todd
1Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford UK.
Nature
|September 19, 1991
概括
研究人员在小鼠中绘制了一种新的糖尿病易感基因,Idd-5. 这一发现有助于更好地了解导致1型糖尿病和相关自身免疫性疾病的遗传因素.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
- 内分泌学 在内分泌学.
背景情况:
- 1型糖尿病是一种影响胰腺β细胞的自身免疫性疾病,具有遗传和环境原因.
- 非肥胖糖尿病 (NOD) 鼠与人类1型糖尿病有遗传和免疫病理上的相似之处.
- 以前的研究在小鼠中发现了三种糖尿病易感基因 (Idd-1至 -4).
研究的目的:
- 在非肥胖糖尿病 (NOD) 小鼠中绘制新型糖尿病易感性基因.
- 在映射区域内识别潜在的候选基因.
- 为了进一步阐明自身免疫性糖尿病的遗传基础.
主要方法:
- 在NOD小鼠中的糖尿病易感位点的遗传映射.
- 对候选基因的小鼠染色体1的分析.
- 在映射区域内对已知的基因进行审查,以确定它们在免疫功能中的潜在作用.
主要成果:
- 一个新的糖尿病易感点,Idd-5,被映射到小鼠染色体1的近位区域.
- 这个区域至少含有两个候选基因:互白素-1受体基因和Lsh/Ity/Bcg.
- Idd-1位点与免疫反应I-Aβ基因有关,它是人类HLA-DQB1.1的同类.
结论:
- 鉴定Idd-5为了解自身免疫性糖尿病遗传学提供了一个新的目标.
- 在Idd-5位点内的候选基因,如互白素-1受体和Lsh/Ity/Bcg,需要进一步调查.
- 在小鼠中了解这些遗传因素可以提供对人类1型糖尿病的见解.
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