维纳卡兰特化用于快速转换心房动:一个第三阶段,随机,安慰剂对照试验
Denis Roy1, Craig M Pratt, Christian Torp-Pedersen
1Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada. d_roy@icm-mhi.com
Circulation
|March 12, 2008
概括
在50%以上的患者中,Vernakalant化物有效地将最近出现的心房动 (AF) 转化为正常的鼻节律. 这种新的治疗方法显示出快速的疗效,并且通常耐受良好,为AF管理提供了新的选择.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 心房动 (AF) 是一种常见的心律失常症,需要有效治疗.
- 弗纳卡兰特化 (RSD1235) 是一种新型化合物,用于AF转换.
- 评估vernakalant的疗效和安全性对于其临床应用至关重要.
研究的目的:
- 评估Vernakalant化在将心房动转化为鼻节律方面的疗效.
- 评估弗纳卡兰特化物在患有AF的患者中的安全性.
- 为了在不同AF持续时间组中比较弗纳卡兰特与安慰剂的有效性.
主要方法:
- 一个随机的,安慰剂对照试验,涉及336名患有AF的患者.
- 患者被分为短期 (3小时至7天) 和长期 (8至45天) AF组.
- 给出了两次注Vernakalant或安慰剂,有效性在90分钟内评估.
主要成果:
- 弗纳卡兰特在51.7%的短期AF患者中迅速将AF转化为鼻腔节律,而安慰剂患者的这一比例为4.0% (P<0.001).
- 总体AF终止发生在37.6%的VERNAKALANT治疗患者中,与2.6%的安慰剂治疗患者相比 (P<0.001).
- 常见的副作用包括过渡性失血症和打喷;严重的不良事件很少发生.
结论:
- 弗纳卡兰特化在快速转化短期心房动方面表现出显著的疗效.
- 该化合物一般耐受性良好,安全性概况可控.
- 弗纳卡兰特代表了一种有前途的治疗选择,用于急性管理最近出现的AF.
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