Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials.

NPJ breast cancer·2025
Same author

Reflections on the pigments of life.

Nature reviews. Chemistry·2025
Same author

Convection Enhanced Delivery in the Setting of High-Grade Gliomas.

Pharmaceutics·2021
Same author

Endpoint in ovarian cancer xenograft model predicted by nighttime motion metrics.

Lab animal·2020
Same author

Diastereoselective generation of triple-stranded helicates induced by gem-dimethyl groups on a linker.

Dalton transactions (Cambridge, England : 2003)·2012
Same author

Synthesis of triple-stranded complexes using bis(dipyrromethene) ligands.

Inorganic chemistry·2010

相关实验视频

Updated: Jul 6, 2026

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
08:54

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

Published on: February 17, 2023

使用可见光进行特定部位的前药物释放.

Michael Y Jiang1, David Dolphin

  • 1Department of Chemistry, University of British Columbia, Room W300 - 6174 University Boulevard, Vancouver, BC, V6T 1Z3, Canada.

Journal of the American Chemical Society
|March 14, 2008
PubMed
概括

一个新的光动力学前药物系统使用可见光从光敏剂复合体释放药物. 这一策略使得有针对性的药物输送和释放成为可能,这在NSAID甲基和与形相关的光敏感剂中得到了证明.

科学领域:

  • 药用化学 医学化学
  • 摄影化学的使用.
  • 药物输送系统 药物输送系统

背景情况:

  • 开发有针对性的药物输送系统对于提高治疗疗效和尽量减少副作用至关重要.
  • 光动力学策略为药物释放提供时空控制,利用光激活.

研究的目的:

  • 开发一种光动力学前药物系统,利用光敏化和单点氧化来控制药物释放.
  • 研究从光敏感剂结合物中加入和光触发释放含有碳烯的药物.

主要方法:

  • 采用了一种光敏化-单片氧化-二氧化裂解策略.
  • 含有碳基的药物被附着在光敏感剂 (与脊椎蛋白相关) 上,形成复合物.
  • 可见光辐射被用来触发药物的释放.

主要成果:

  • 开发的系统成功地从光敏化剂合物中释放了仿制药和NSAID甲基.
  • 在可见光照明后,药物释放在几分钟内实现.
  • 观察到释放的药物的产量高到定量.

结论:

  • 一个多功能光动力学前药物系统已成功开发,用于向药物释放.

更多相关视频

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
11:20

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

Published on: August 30, 2017

相关实验视频

Last Updated: Jul 6, 2026

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
08:54

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

Published on: February 17, 2023

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
11:20

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

Published on: August 30, 2017

  • 可见光介导的单片氧生成提供了一个在现场精确激活药物的机制.
  • 这种方法对需要局部药物输送的先进治疗应用具有前景.