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Updated: May 3, 2026

Assays for the Degradation of Misfolded Proteins in Cells
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Published on: August 28, 2016

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聚聚胺扩张对原生蛋白质复合物的相反作用有助于SCA1的产生

Janghoo Lim1, Juan Crespo-Barreto, Paymaan Jafar-Nejad

  • 1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.

Nature
|March 14, 2008
PubMed
概括

1型脊髓小脑动症 (SCA1) 涉及由于扩大了谷氨酸重复的毒性蛋白质功能. 这项研究揭示了SCA1是由改变的蛋白质复合体形成引起的,涉及功能增益和功能丧失机制.

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