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SATB1重新编程基因表达以促进乳腺瘤生长和转移

Hye-Jung Han¹, Jose Russo, Yoshinori Kohwi

¹Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA.

|March 14, 2008

概括

基因组组织者SATB1通过改变基因表达和染色体组织来驱动侵袭性乳腺癌. 它的抑制逆转了瘤发生,而它的表达促进了侵略性的表型和转移.

科学领域:

分子生物学分子生物学
遗传学遗传学是一种遗传学.
癌症研究癌症研究

背景情况:

瘤进展期间全球基因表达变化的机制尚不清楚.
SATB1是一种基因组组织者,影响着染色质结构和基因表达.

研究的目的:

研究SATB1在乳腺癌进展和转移中的作用.
阐明SATB1影响瘤攻击性的机制.

主要方法:

在侵袭性乳腺癌细胞 (MDA-MB-231) 中,RNA干扰介导的SATB1敲除.
在非侵袭性乳腺癌细胞 (SKBR3) 中的宫外SATB1表达.
在体内对基因表达变化,染色质修饰和瘤生长/转移的分析.

主要成果:

SATB1的表达与侵袭性乳腺癌和不良预后有显著的相关性.
SATB1敲击逆转了瘤发生,恢复了极性,并抑制了生长/转移.
宫外SATB1表达诱导了侵略性表型和转移性活动.
通过表观遗传修饰,SATB1通过表观遗传修饰上调转移基因和下调瘤抑制基因.

结论:

SATB1作为一种驱动乳腺瘤生长和转移的新奇机制.
在侵袭性乳腺癌中,SATB1重新编程染色质组织和转录资料.

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