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Updated: Jul 6, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

计算机模拟研究了DNA接层状双氧化物结构稳定性和材料特性

Mary-Ann Thyveetil1, Peter V Coveney, H Chris Greenwell

  • 1Centre for Computational Science, Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom.

Journal of the American Chemical Society
|March 19, 2008
PubMed
概括

在基因疗法和生命起源研究中,将DNA插入到分层双氧化物 (LDH) 中是关键. 分子动力学模拟显示,在极端条件下,LDHs内增强了DNA稳定性,这对于了解早期生命至关重要.

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The DNA Helix01:07

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
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The DNA Helix

Overview
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DNA Topoisomerases

Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
Types and Mechanism of action
Topoisomerases are divided into two main types.  Type I...