偏氧酶1 (PON1) 基因多态和功能活性与全身氧化应激和心血管风险的关系
Tamali Bhattacharyya1, Stephen J Nicholls, Eric J Topol
1Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA.
JAMA
|March 20, 2008
概括
偏氧酶1 (PON1) 基因型影响活性,影响氧化应激和心血管疾病风险. 较低的PON1活性和特定的基因型与增加的死亡率和主要的不良心脏事件有关.
科学领域:
- 生物化学 生物化学
- 遗传学 遗传学 是一个
- 心脏病学 心脏病学
背景情况:
- 氧酶1 (PON1) 具有抗氧化和心脏保护性质.
- 需要系统地调查PON1基因型,活性,氧化应激和心血管疾病 (CVD) 风险之间的相互作用.
研究的目的:
- 探索PON1活动的遗传和生化因素与全身氧化应激标志物和人类心血管疾病风险的关联.
主要方法:
- 评估了1399名接受冠状动脉动脉扫描的患者,研究了PON1活性,Q192R多态性,流行心血管疾病和未来重大心脏不良事件之间的关联.
- 在150名匹配患者中通过质谱测量脂肪酸氧化产品的全身水平,根据PON1基因型和活性进行比较.
主要成果:
- PON1基因型 (QQ192 > QR192 > RR192) 与PON1活性降低和系统氧化应激增加相关.
- 与RR192/QR192.2相比,QQ192基因型与所有原因死亡率 (aHR,2.05) 和主要心脏不良事件 (aHR,1.48) 的风险较高有关.
- 最高的PON1活性四分位数显示,主要不良心脏事件发生率明显较低 (7.3-7.7%),而较低的四分位数 (23.5-25.1%).
结论:
- 建立了PON1遗传决定因素,活性,全身氧化应激和潜在心血管风险之间的机制联系.
- 这表明PON1的动脉保护功能存在潜在的机制.
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