在Li-Fraumeni综合征中进行F18-氧葡萄糖-正电子发射断层扫描/计算机断层扫描查
Serena Masciari1, Annick D Van den Abbeele, Lisa R Diller
1Division of Population Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
JAMA
|March 20, 2008
概括
阳位子发射断层扫描/计算机断层扫描 (PET/CT) 扫描可以检测Li-Fraumeni综合征 (LFS) 患者的早期癌症. 这项试点研究在20%的参与者中发现了无症状恶性瘤,这表明PET/CT是潜在的监测工具.
科学领域:
- 在瘤学瘤学.
- 医疗成像医学成像
- 遗传学 遗传学 是一个
背景情况:
- 李-弗劳梅尼综合征 (LFS) 是由于TP53基因突变导致的遗传性癌症倾向,导致各种早期发病的癌症.
- 在LFS幸存者中存在额外原发性瘤的高风险,这使查建议复杂化.
研究的目的:
- 评估F18-氧葡萄糖-正子发射断层扫描/计算机断层扫描 (FDG-PET/CT) 作为一种监测工具,用于在无症状LFS个体中早期发现癌症.
- 收集关于FDG-PET/CT在识别新的原发性恶性瘤中的疗效的初步数据.
主要方法:
- 2006-2007年间,从LFS家族中带有生殖系TP53突变的无症状个体被纳入.
- FDG-PET/CT扫描作为查测试进行,并由放射科医生审查.
- 主要结局是检测出新的原发性癌症.
主要成果:
- 在15名 (20%) 参与者中,FDG-PET/CT在3名参与者中发现了无症状癌症.
- 检测到的癌症包括两种乳头甲状腺癌 (第二阶段和第三阶段) 和一种第二阶段食道腺癌.
结论:
- 初步发现表明FDG-PET/CT可能是LFS患者可行的癌症监测策略.
- 考虑到辐射暴露和高风险人群的查挑战,需要进一步调查.
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