热蛋白在茎中触发了光周期反应
Nobuhiro Nakao1, Hiroko Ono, Takashi Yamamura
1Division of Biomodelling, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
Nature
|March 21, 2008
概括
在下丘脑中,甲状腺激素激活酶 (DIO2) 和甲状腺激素 (TSH) 基因表达启动了日本的季节性繁殖. TSH刺激淋巴体生长和DIO2表达,触发长日诱导生殖.
科学领域:
- 内分泌学 在内分泌学.
- 神经内分泌学神经内分泌学
- 生殖生物学 生殖生物学
背景情况:
- 响应光周期变化的动物季节性繁殖的分子基础在很大程度上是未知的.
- 在光周期信号转导中观察到的最早的事件是日本长下丘脑中2型二氧化酶 (DIO2) 基因表达的快速诱导.
研究的目的:
- 为了阐明白中基底下垂体 (MBH) 中的基因表达级联,启动光诱导的素激素分泌.
- 调查甲状腺素 (TSH) 在触发季节性繁殖中的作用.
主要方法:
- 在长日暴露后, MBH 中基因表达波的分析.
- 内内 (ICV) 的TSH给短日的管理.
- 对TSH受体循环AMP (cAMP) 信号通路的研究.
主要成果:
- 在MBH中发现了两种不同的基因表达波.
- 第一个波动涉及TSHβ子单元表达在茎体中的增加,其次是增加DIO2表达.
- 在TSH受体-cAMP通路的介导下,TSH的ICV给药刺激了 gonadal生长和DIO2表达在短日乌中.
结论:
- 帕斯结核菌中的TSH增加似乎是长日光诱导季节性繁殖的触发因素.
- 这项研究揭示了一种涉及TSH和DIO2在光周期调节繁殖的新信号通路.
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