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Updated: Jun 27, 2026

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通过REST降解,SCFbeta-TRCP控制瘤转化和神经分化

Thomas F Westbrook1, Guang Hu, Xiaolu L Ang

  • 1Howard Hughes Medical Institute, Department of Genetics, Harvard Partners Center for Genetics and Genomics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

Nature
|March 21, 2008
PubMed
概括

RE1沉默转录因子 (REST) 被SCF (β-TRCP) 复合体降解,这是神经分化的一个关键步骤. 这一途径也与β-TRCP驱动的癌症发展有关.

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